Potential harm in acting before there’s ‘good science’

09 April 2020 | Story Carla Bernardo. Voice Munashe Makado. Read time 6 min.
UCT&rsquo;s Dr Kate Webb is a co-author in an international response to a study that has reported that hydroxychloroquine, a medication used to treat lupus, was useful in the treatment of COVID-19. <strong>Photo </strong><a href="https://www.pexels.com/photo/syringe-and-pills-with-petri-dish-3786124/" target="_blank">Pexels</a>.
UCT’s Dr Kate Webb is a co-author in an international response to a study that has reported that hydroxychloroquine, a medication used to treat lupus, was useful in the treatment of COVID-19. Photo Pexels.

An international team of doctors and researchers recently responded to a preprint study on the use of hydroxychloroquine in the treatment of Coronavirus Disease 2019 (COVID-19). The response identifies multiple issues with the study’s design and data. One of the co-authors of the response is the University of Cape Town’s (UCT) Dr Kate Webb.

Webb is a paediatric rheumatologist in UCT’s Department of Paediatrics and Child Health and the second academic from the university to be selected for the prestigious Crick African Network’s African Career Accelerator awards. She is also UCT’s regional lead in the COVID-19 Global Rheumatology Alliance, which brings together people with pre-existing rheumatic diseases, like lupus and arthritis, and the doctors who look after them.

The response she helped to compile is titled “A rush to judgment? Rapid reporting and dissemination of results and its consequences regarding the use of hydroxychloroquine for COVID-19.

The study reported that hydroxychloroquine, a medication used to treat lupus, was useful in the treatment of COVID-19. According to the study, people with COVID-19 who had received hydroxychloroquine and azithromycin cleared the virus more quickly than people who did not.


“It is potentially harmful to act before we have good science.”

Following its publication, there was widespread dissemination of the study’s findings in media and by politicians who started speaking about hydroxychloroquine as a “miracle drug” for COVID-19. While it may well turn out to be the case, Webb warned that there is “just not enough good evidence for this at this stage” and it will remain unknown “until good science gives us data”.

Thus, the co-authors of “A rush to judgment?” found that the study was poorly designed and had some serious methodological problems. Of the multiple issues identified, Webb explained that not all participants in the study started the same, with the same amount of virus.

In addition to this, three out of 26 people who received hydroxychloroquine were admitted to an intensive care unit and one died. Instead of including these as “bad outcomes”, they were excluded from the statistical analysis.

Real-world dangers

The “rush to judgement” of the study has introduced real-world dangers and implications for Webb’s lupus patients. Lupus, she explained, is a serious disease involving multiple organ systems, and chloroquine or hydroxychloroquine is a standard and life-saving treatment.

Dr Kate Webb said she is “extremely motivated and inspired” by the response of her colleagues in academia to the pandemic. Photo Supplied.

Because of the attention the study has received, the world’s supply of hydroxychloroquine has dwindled, leaving patients who desperately need it in trouble; there have been widespread reports of hydroxychloroquine shortages and patients with lupus struggling to get medication.

“Although there is a real need to move quickly in finding drugs that work for COVID-19, it is potentially harmful to act before we have good science.”

Research challenges

Webb stressed that the pandemic has amplified pressure on those conducting research. These include challenges around working quickly, effectively and streamlining a lot of the usual bureaucracy that exists in academia.

“There is, however, a real risk when moving this fast of making mistakes, and the ethical questions around the risks to privacy still need to be very carefully worked through,” she said.

Webb added that there are also real risks to staff and participants – risks that must be carefully thought through and prevented.


“Working together to gather information and supporting each other is our best weapon against COVID-19.”

There are many more challenges affecting researchers and adding to the pressure. This includes working remotely with international teams, often while caring for young children or recovering from COVID-19, and the fact that most of the research being conducted before the pandemic has since been suspended. Additionally, many researchers have been called to the frontline to either clinically respond or to help with testing.

Personally, Webb is “extremely motivated and inspired” by the response of her colleagues in academia. But while working hard has been her coping strategy, even she is struggling to conduct good research and assist in the clinical response while also caring for her young family.

“Everyone is being pushed to their limits with this and I have been amazed at how the scientific community has responded; we are getting things done in weeks that would have taken years previously.”

Our best weapon

“The broader public has been amazing in its response to COVID-19,” said Webb. “We appreciate people following advice and staying at home to protect us and our families while we do this important work.”

She added that those who are working hard to keep data networks running, shops open and stocked with food, houses safe and the lights on “are all supporting this research”.

Combatting diseases like COVID-19, research is crucial, said Webb, and there is a moral obligation to use every new case as a learning opportunity.

“Therefore, we would like to ask the public that if they are offered the chance to participate in research that has been approved by their local ethics committee, they consider it carefully.

“Working together to gather information and supporting each other is our best weapon against COVID-19.”

Creative Commons License This work is licensed under a Creative Commons Attribution-NoDerivatives 4.0 International License.

Please view the republishing articles page for more information.

Coronavirus Disease 2019 updates

COVID-19 is a global pandemic that caused President Cyril Ramaphosa to declare a national disaster in South Africa on 15 March and implement a national lockdown from 26 March.

UCT is taking the threat of infection in our university community extremely seriously, and this page will be updated regularly with the latest COVID-19 information.

Campus updates

  •  Information
  •  Normal
  •  Caution
  •  Alert

Daily updates

Friday, 5 February 14:20, 5 February 2021
Monday, 4 January 16:50, 4 January 2021
Friday, 18 December 11:30, 18 December 2020
Thursday, 19 November 09:30, 19 November 2020
Friday, 13 November 12:40, 13 November 2020
Friday, 16 October 10:05, 16 October 2020
Wednesday, 14 October 12:50, 14 October 2020
Tuesday, 22 September 14:10, 22 September 2020
Friday, 11 September 10:05, 11 September 2020
Monday, 31 August 12:20, 31 August 2020
Wednesday, 12 August 10:20, 12 August 2020
Friday, 7 August 11:24, 7 August 2020
Thursday, 6 August 18:26, 6 August 2020
Monday, 27 July 14:00, 27 July 2020
Wednesday, 15 July 09:30, 15 July 2020
Monday, 13 July 14:25, 13 July 2020
Monday, 6 July 16:20, 6 July 2020
Thursday, 25 June 10:15, 25 June 2020
Tuesday, 23 June 12:30, 23 June 2020
Thursday, 18 June 17:35, 18 June 2020
Wednesday, 17 June 10:45, 17 June 2020
Tuesday, 2 June 12:20, 2 June 2020
Friday, 29 May 09:25, 29 May 2020
Monday, 25 May 14:00, 25 May 2020
Thursday, 21 May 12:00, 21 May 2020
Wednesday, 6 May 10:00, 6 May 2020
Tuesday, 5 May 17:05, 5 May 2020
Thursday, 30 April 17:10, 30 April 2020
Tuesday, 28 April 10:30, 28 April 2020
Friday, 24 April 09:35, 24 April 2020
Thursday, 23 April 17:00, 23 April 2020
Wednesday, 22 April 14:25, 22 April 2020
Monday, 20 April 17:45, 20 April 2020
Friday, 17 April 12:30, 17 April 2020
Thursday, 16 April 09:45, 16 April 2020
Tuesday, 14 April 11:30, 14 April 2020
Thursday, 9 April 09:00, 9 April 2020
Wednesday, 8 April 15:40, 8 April 2020
Wednesday, 1 April 15:50, 1 April 2020
Friday, 27 March 11:40, 27 March 2020
Thursday, 26 March 18:30, 26 March 2020
Tuesday, 24 March 15:40, 24 March 2020
Monday, 23 March 15:40, 23 March 2020
Friday, 20 March 16:00, 20 March 2020
Thursday, 19 March 09:15, 19 March 2020
Wednesday, 18 March 16:00, 18 March 2020
Tuesday, 17 March 12:50, 17 March 2020
Monday, 16 March 17:15, 16 March 2020

Campus communications

New SRC and other updates 16:44, 4 November 2020
Virtual graduation ceremonies 13:30, 21 October 2020
Online staff assembly and other updates 15:09, 30 September 2020
Fee adjustments and other updates 15:21, 16 September 2020
Call for proposals: TLC2020 10:15, 26 August 2020
SAULM survey and other updates 15:30, 5 August 2020
COVID-19 cases and other updates 15:26, 5 August 2020
New UCT Council and other updates 15:12, 15 July 2020
Upcoming UCT virtual events 09:30, 15 July 2020
Pre-paid data for UCT students 14:25, 22 April 2020
Update for postgraduate students 12:55, 20 April 2020
UCT Human Resources and COVID-19 16:05, 19 March 2020
UCT confirms second COVID-19 case 09:15, 19 March 2020
Update on UCT COVID-19 response 13:50, 11 March 2020
Update on COVID-19 17:37, 6 March 2020


Video messages from the Department of Medicine

Getting credible, evidence-based, accessible information and recommendations relating to COVID-19

The Department of Medicine at the University of Cape Town and Groote Schuur Hospital, are producing educational video material for use on digital platforms and in multiple languages. The information contained in these videos is authenticated and endorsed by the team of experts based in the Department of Medicine. Many of the recommendations are based on current best evidence and are aligned to provincial, national and international guidelines. For more information on UCT’s Department of Medicine, please visit the website.

To watch more videos like these, visit the Department of Medicine’s YouTube channel.

Useful information from UCT

External resources

News and opinions

Statements and media releases

Media releases

Read more  

Statements from Government


In an email to the UCT community, Vice-Chancellor Professor Mamokgethi Phakeng said:
“COVID-19, caused by the virus SARS-CoV-2, is a rapidly changing epidemic. [...] Information [...] will be updated as and when new information becomes available.”


We are continuing to monitor the situation and we will be updating the UCT community regularly – as and when there are further updates. If you are concerned or need more information, students can contact the Student Wellness Service on 021 650 5620 or 021 650 1271 (after hours), while staff can contact 021 650 5685.