UCT marked the International AIDS Candlelight Memorial at a concert on 14 May, earlier than the official commemoration on 17 May.
Rising star Nomfusi took centre stage with her own HIV/AIDS message, opening with a song written for her mother, whom she lost to AIDS when she was 12.
Acting Vice-Chancellor Professor Thandabantu Nhlapo called on the UCT community to think more deeply about their roles in creating an environment where HIV-positive students and staff "will feel equal in a safe space".
Students' Representative Council president, Chris Ryall, said student activism around HIV/AIDS should be the issue on campus.
"HIV and AIDS are as much about social justice and transformation as anything else."
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